- Guidelines
Eligibility and internal materials in black are for general translational applications. The same materials are due for All-Star applications + the additional items in red.
Objectives: This Translational grant is restricted to adult cancer research in the preclinical or translational space with a focus on bench-to-bedside strategies. Research on ANY adult cancer type can be funded. Applicants may propose cancer research that moves a novel strategy from the laboratory into a human clinical trial or uses specimens from a clinical trial to test hypotheses, develop biomarkers, or mechanisms. The research must apply in a direct way to human beings within 3 years from the end of the grant. If biomarker research is undertaken, a validation set or independent clinical trial is essential. A plan for biomarker validation, if applicable, must be included in any proposal. The endpoint of the project should be the planning or initiation of a new clinical trial or conducting an investigator-initiated trial with laboratory correlates that test hypotheses. Research areas not included in this scope are epidemiology, behavioral science, and health services research.
Grant Specifics:
- A four-year, $800,000 grant, paid in $200,000 annual installments. Indirect costs up to 10% of direct costs allowed.
- The V Foundation follows NIH Guidelines regarding salary caps. Institutions may supplement a grant recipient’s salary with institutional funds, if desired.
Applicant Eligibility:
- Nominated by their Cancer Center Director or similar high ranking research official (will occur at internal review)
- Employed at a non-profit research institution (e.g., 501c3, Section 170).
- Must be either a US Citizen or have a legal permit (temporary or permanent) to work in the US. This requirement does not apply to invited Canadian institutions.
- Hold a full-time faculty appointment at the Assistant Professor or Assistant Professor-equivalent level or above. Non-promotable, adjunct, affiliated, temporary, part-time or acting faculty positions are not eligible for Principal Investigator nomination.
- Must have previously been awarded a V Foundation research grant as the lead PI and must meet at least ONE of the following criteria by the nomination deadline:
- Have a completed V Foundation research grant or
- Be in the final year of an active V Foundation grant (received final payment and on track to finish by grant end date).
- Must have been the lead PI on the V Foundation research grant from start to finish.
- Must have all financial and progress reports up to date.
- Must not have a current V Foundation All-Star grant.
- Must not have only received V Foundation non-research/Mission grant(s).
REQUIRED MATERIALS FOR INTERNAL REVIEW:
- Cover Page: PI Name, Project Title, Key Words, Track (Translational or All-Star Translational) – format/style up to applicant.
- Biosketch
- 3-page proposal (including illustrations; references can be separate)
- A biostatistical or bioinformatics plan
- Confirmation of prior V Foundation award
A budget is not required for the internal application to identify a nominee.